November/December 2003 Articles
Editorial
Topic Focus: Biomarkers: Present Concepts and Future Promise
J.C. Lindon
Full Text (60K PDF)
News
Trouble in Paradise: RNA Interference Beset With New Complexity
J. Ashkenas
Full Text (72K PDF)
Radiotherapy for Infectious Disease
B. Reid
Full Text (68K PDF)
Individually Tailored Multiple Sclerosis Vaccines: Proteomics Meets Autoimmunity
M. Fogarty
Full Text (58K PDF)
ADDL'd by Alzheimer's
K. Kleiner
Full Text (72K PDF)
Topic Focus: 21 CFR Part 11 Revamped as the FDA Embraces
A. DePalma
Full Text (53K PDF)
The Madey Decision and Academic Research: Has the Sky Fallen?
S. Redfearn
Full Text (52K PDF)
SARS Gives Pharma a Case of Altruism
J. Ashkenas
Full Text (57K PDF)
Commentary
Opinion pieces from invited writers on topics of interest to Preclinica readers, such as regulatory guideline clarifications, issues in drug development in academia vs. industry, ethical issues, and specific scientific and preclinical drug development issues.
Regulatory Forum
Topic Focus: 21 CFR Part 11: Where Are We Now?
W. Goebel
Full Text (95K PDF)
Regulatory Forum
Topic Focus: The Implications of Part 11 in the New Development Paradigm
M. Pontinen and J.L. Gagnon
Full Text (115K PDF)
Topic Focus: The Biomarker Road to Redemption
S. Naylor
Full Text (47K PDF)
Topic Focus: Pitfalls to Using Small Animals in Preclinical Testing Are Being Eliminated
M. Chandler and M. Spain
Full Text (47K PDF)
Topic Focus: Reducing the Risk of Drug Discovery: The Application of Predictive Modeling to Preclinical Development
R.W. Gerwien and C.L. Hyde
Full Text (152K PDF)
Social Pharmacology and Preclinical Drug Research
M. Montagne
Full Text (105K PDF)
Research Articles
Full peer-reviewed primary data manuscripts covering any of the topics listed in the mission and scope of Preclinica. Includes descriptions of new technical breakthroughs along with "proof-of-concept" data. Review articles on current preclinical technologies and methods are also highlighted.
Potential Roles for Saccharomyces cerevisiae to Model Pantothenate and Coenzyme A Metabolic Dysfunction in Hallervorden-Spatz Syndrome
W.H. White
Abstract | Full Text (383K PDF)
Small Interfering RNA Molecules as Potential Anti-Human Hepatitis C Virus Agents: Identification and Characterization of Two siRNA Molecules Highly Conserved in the Major Genotypes of the Virus
A. Martinez, W.J. Yang, X.C. Chen, C.M. Love, L. Jin, A. Glasebrook, and G. Zhao
Abstract | Full Text (269K PDF)
Comparative Toxicity of Arginine Deiminase Formulated with Poly(Ethylene Glycol) 5000 or 20,000 and the Effects of Arginine
J .S. Bomalaski, J.L. Ivett, M. Vegarra, F.W. Holtsberg, C.M. Ensor, and M.A. Clark
Abstract | Full Text (288K PDF)
Products and Services
New Products and Services for Preclinical Development
Full Text (74K PDF)
