January/February 2004 Articles
Editorial
Topic Focus: Interference at the Preclinical Boundaries
K.C. Reed
Full Text (59K PDF)
News
Targeting Excitotoxicity
M. Fogarty
Full Text (55K PDF)
Topic Focus: Apt Pupils: Nucleic Acid Drugs for Eye Disease
J. Ashkenas
Full Text (114K PDF)
Topic Focus: Selective Tumor Lysis with RNA Viruses
A. DePalma
Full Text (42K PDF)
Harnessing Phage Display for Chemical Library Screening
K. Kleiner
Full Text (99K PDF)
Topic Focus: Making Monoclonal Antibodies Cheaper by the Pound
J. Alper
Full Text (87K PDF)
Retail Private Placements: The Fundraising Route Less Traveled
M. Fogarty
Full Text (64K PDF)
Commentary
Opinion pieces from invited writers on topics of interest to Preclinica readers, such as regulatory guideline clarifications, issues in drug development in academia vs. industry, ethical issues, and specific scientific and preclinical drug development issues.
Regulatory Forum
The Spirit of Volunteerism Help Set the USP-NF Standards for Pharmaceutical Substances and Products
R. Dabbah
Full Text (91K PDF)
Topic Focus: Scalable Cell Harvest Technologies
J.M. Jenco
Full Text (199K PDF)
Topic Focus: Immunoconjugates: A Therapy Whose Time Has Come?
C.W. Jorgensen and K.J. Morrow, Jr.
Full Text (125K PDF)
The Importance of Biotech Research in Developing New Weapons Against Bioterrorism
A. Kang
Full Text (62K PDF)
The Virtual Patient: Capturing Patient Variability Using Biosimulation
S. Michelson and M. Okino
Full Text (306K PDF)
Topic Focus: Adult Stem Cells for Tissue Repair
M. Körbling and Z. Estrov
Full Text (287K PDF)
Research Articles
Full peer-reviewed primary data manuscripts covering any of the topics listed in the mission and scope of Preclinica. Includes descriptions of new technical breakthroughs along with "proof-of-concept" data. Review articles on current preclinical technologies and methods are also highlighted.
Topic Focus: Toxicology and Biodistribution Studies of a Recombinant Adeno-Associated Virus 2-a-1 Antitrypsin Vector
A. Poirer, M. Campbell-Thompson, Q. Tang, M. Scott-Jorgensen, L. Combee, S. Loiler, J. Crawford, S. Song, and T.R. Flotte
Abstract | Full Text (328K PDF)
Unique Protein Screening Analysis of Stimulated Whole Saliva from Healthy Individuals and Breast Cancer Patients
L.G. Bigler and C.F. Streckfus
Abstract | Full Text (167K PDF)
A Novel Assessment System for Bisphosphonates Using Mouse RAW264 Cells and Biometic Hydroxyapatite-Coated Plates
N. Sakai, T. Ogawa, S. Koga, H. Samori, K. Yogo, N. Ishida, and T. Takeya
Abstract | Full Text (477K PDF)
Topic Focus: Preclinical Studies with Plant-Produced a-Galactosidase A in Fabry Mice Show Potential for Replacement Therapy
M.P. Gelderman, K.L. Oliver, A.T. Yazdani, G.J. Murray, G.F. Miller, T.I. Cameron, S.J. Garger, T.H. Turpen, R.B. Holtz, and R.O. Brady
Abstract | Full Text (276K PDF)
Products and Services
New Products and Services for Preclinical Development
Full Text (117K PDF)
