November/December 2004 Articles
Editorial
Topic Focus: New Models for Cancer Research in Zebrafish
J.P. Kanki
Full Text (HTML)
And Now For Something Completely Different
B. VanRenterghem
Full Text (HTML)
News
The Evolution of SELEX
J. Ashkenas
Full Text (49K PDF)
A Ghrelin Antagonist at Last
J. Ashkenas
Full Text (70K PDF)
Tackling Tumor Drug Resistance
J. Ashkenas
Full Text (48K PDF)
Commentary
Opinion pieces from invited writers on topics of interest to Preclinica readers, such as regulatory guideline clarifications, issues in drug development in academia vs. industry, ethical issues, and specific scientific and preclinical drug development issues.
Regulatory Forum
Topic Focus: Current Status and Validation of Alternative Testing Models in Preclinical Development
R. Konsoula and F.A. Barile
Full Text (151K PDF)
Regulatory Forum
Biomarkers in the Development of Oncology Drug Products: Can They Make a Difference?
L.A. Rosario
Full Text (122K PDF)
Topic Focus: Trials and Tribulations in the Search for Stroke Drugs
S.H. Curry
Full Text (196K PDF)
Functional Genomics in the Clinic: A Path Toward Personalized Medicine
D.M. Kemp and J.F. Habener
Full Text (167K PDF)
Merits of a Specialty Contract Research Organization
J.F. Pesek, R.G. Peterson, and T.A. Gobbett
Full Text (94K PDF)
RNAi as a Drug Target Identification and Validation Tool: Current Status and Novel Trends
D.A. Samarsky and P.J. Welch
Full Text (92K PDF)
Adeno-Associated Viral Vectors for Cardiovascular Gene Therapy: Current Perspectives
A.H. Baker
Full Text (285K PDF)
Topic Focus: Is Early Absorption Screening Useful in the Selection of Drug Candidates?
G.W. Caldwell and D.M. Ritchie
Full Text (148K PDF)
Research Articles
Full peer-reviewed primary data manuscripts covering any of the topics listed in the mission and scope of Preclinica. Includes descriptions of new technical breakthroughs along with "proof-of-concept" data. Review articles on current preclinical technologies and methods are also highlighted.
Review
Topic Focus: Animal Models for Better Antidepressants: Can Pathogenetic Approaches Make a Difference?
J. Harro
Abstract | Full Text (185K PDF)
Review
Combinatorial Strategies Towards Spinal Cord Repair: Enhancement of the Schwann Cell Bridge and Modification of the Graft-Host Interface
C.H. Chau, D.K.Y. Shum, and X.-M. Xu
Abstract | Full Text (272K PDF)
Review
Topic Focus: Drug Addiction: What Can Animal Models Teach Us?
N.L. Schramm-Sapyta
Abstract | Full Text (190K PDF)
Review
Tumor-Host Interactions
L. Yan, L. Shahied, Y. Tang, P. Kesavan, and M.T. Nakada
Abstract | Full Text (185K PDF)
Effects of Lipopolysaccharide on Toxicologically Important Endpoints in Cynomolgus Macaques
K.M. Picha, S.H. Tam, V.S. Khandekar, A.R. Soderman, E.C. Martin, R.E. Jordan, and P.J. Bugelski
Abstract | Full Text (303K PDF)
Comprehensive Assessment of Cell Growth Properties Using an Integrated and Nonsubjective Approach
G. Claassen, N. Ke, D. Yu, J.E. Chatterton, X. Hu, A. Albers, V. Nguy, J. Chionis, T. Truong, B. Meyhack, F. Wong-Staal, and Q.-X. Li
Abstract | Full Text (240K PDF)
Topic Focus: Subchronic Phencyclidine: A Rat Model of Schizophrenia - Medial Prefrontal Cortex Pyramidal Neuron Properties and GABAA-Mediated Synaptic Transmission
B. Yu, L. Orozco-Cabal, J. Liu, and J.P. Gallagher
Abstract | Full Text (1.5MB PDF)
Topic Focus: Development of a Clinically Applicable Cancer Immunotherapy Strategy Based on Human Dendritic Cells Modified with Recombinant Fowlpox
Y. Tanaka, K. Colling, M. Ghanayem, A. Hobeika, D. Panicali, J. Schlom, K.-Y. Tsang, T. Osada, H.K. Lyerly, T.M. Clay, and M.A. Morse
Abstract | Full Text (495K PDF)
Effects of Rapamycin Derivative ABT-578 on Canine Smooth Muscle Cells and Endothelial Cell Proliferation
L. Xue, R. Sharma, K. Cochran, A.K. Tassiopoulos, J. Jara-Almonte, K. Cromack, J. Zage, N. Wilding, P.J. Tarcha, and H.P. Greisler
Abstract | Full Text (216K PDF)
Products and Services
New Products and Services for Preclinical Development
Full Text (62K PDF)
